The PTFE lined corrosion-resistant regulating valve adopts a fluorine lined (F4, F46, PFA) structure for both the valve body and internal components, effectively blocking the corrosion of metal materials in the valve by corrosive media. The inner cavity of the metal valve body is processed by tooth type machining. Fully bond the lining material with the metal, extending the service life and performance of the lining material. The valve stem seal can be a combination of fluorine lined corrugated pipe seal and PTFE packing seal, completely eliminating the possibility of medium leakage from the valve stem to the outside. The unbalanced fully lined structure is particularly suitable for use in highly corrosive media under low pressure and room temperature conditions. The parts of the valve body contacting the corrosive medium are all made of corrosion resistant and anti-aging polyfluoroethylene propylene, high-pressure fluorine plastic lining process, and sealed with polytetrafluoroethylene bellows. It has precise control over the flow rate of high-strength corrosive media such as acids and alkalis, as well as toxic volatile gases and liquids.